Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays


Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function.

30 comments:

  伯函

May 17, 2010 at 6:47 PM

欣賞是一種美德~回應是最大的支持^^.............................................

  Anonymous

May 27, 2010 at 9:52 AM

仇恨是一把雙刃劍,傷了別人,也傷了自己..................................................

  Syed

May 28, 2010 at 3:08 AM

What is the password to open the pdf book?? you did not include any password related info..

  Anonymous

June 3, 2010 at 12:20 AM

失去金錢的人,失去很多;失去朋友的人,失去更多;失去信心的人,失去所有。..................................................

  Anonymous

June 6, 2010 at 6:28 PM

生活盡可低,志氣當高潔........................................

  Anonymous

June 13, 2010 at 3:52 PM

快下班囉~來問個安,跟您打聲招呼 ........................................

  Anonymous

June 13, 2010 at 3:52 PM

you always know the right thing to say!............................................................

  Anonymous

June 21, 2010 at 12:37 AM

人生都有不如意的時候~ 但你的BLOG帶給大家愉快的心情.................................................................

  Anonymous

June 26, 2010 at 12:36 AM

期待你每一篇文章......................................................................

  Anonymous

June 29, 2010 at 5:19 AM

河水永遠是相同的,可是每一剎那又都是新的。.................................................................

  Anonymous

July 3, 2010 at 12:21 AM

成熟,就是有能力適應生活中的模糊。.................................................................

  Anonymous

July 7, 2010 at 3:44 AM

向著星球長驅直進的人,反比踟躕在峽路上的人,更容易達到目的。............................................................

  Anonymous

July 9, 2010 at 5:36 PM

人有兩眼一舌,是為了觀察倍於說話的緣故。............................................................

  Anonymous

July 11, 2010 at 4:28 PM

看著你的BLOG 好多朋友都回應 真厲害..................................................................

  Anonymous

July 13, 2010 at 9:24 PM

時間可證明一切~你的BLOG是我覺得不賴的..................................................................

  Anonymous

July 16, 2010 at 5:37 AM

I have nothing to offer but blood, toil, tears and sweat..................................................................

  Anonymous

July 18, 2010 at 8:52 PM

Say not all that you know, believe not all that you hear.............................................................

  Anonymous

July 21, 2010 at 4:15 AM

Nothing comes from nothing.............................................................

  Anonymous

July 23, 2010 at 10:47 PM

死亡是悲哀的,但活得不快樂更悲哀。. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  Anonymous

July 26, 2010 at 8:16 PM

文章是心情的反應~~祝妳天天寫的都是讓人開心的好文章哦!!...............................................................

  Anonymous

July 29, 2010 at 9:02 PM

正點喔 多謝大大無私的分享 感恩拉( ̄∀ ̄)......................................................

  Anonymous

August 2, 2010 at 12:18 AM

良言一句三冬暖,惡語傷人六月寒。......................................................................

  Anonymous

August 5, 2010 at 1:37 AM

與人相處不妨多用眼睛說話,多用嘴巴思考. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  Anonymous

August 7, 2010 at 5:27 PM

謝謝大大的分享 我會學會反省與寬容 感恩 ∩△∩............................................................

  Anonymous

August 10, 2010 at 3:34 AM

Quality is better than quantity...................................................................

  Anonymous

August 12, 2010 at 7:41 PM

心平氣和~祝你也快樂~~..................................................

  Anonymous

August 14, 2010 at 8:30 PM

幸福不是一切,人還有責任。..................................................... ............

  Anonymous

August 17, 2010 at 12:11 AM

Joy often comes after sorrow, like morning after night.. . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  Anonymous

August 21, 2010 at 10:01 PM

好熱鬧喔 大家踴躍的留言 讓部落格更有活力..................................................