Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function.

Thinking about Biology

Intended for biology students, this philosophical commentary on biology makes science students' studies
more interesting by offering an easy way of studying the philosophy of science, as well as engaging in debates about the social and political implications of biology. It is a unique biology textbook because it adopts an explicitly philosophical approach.

Microbiological Applications:

The classic resource for undergraduate microbiologz laboratory courses just keeps getting better. The self-contained, clearly illustrated exercises and four-color format make Benson's Microbiological Applications: A Laboratory Manual in General Microbiology the ideal lab manual. Appropriate for either a majors or non-majors lab course, Benson assumes no prior organic chemistry
course has been taken.

Schaum's Outline of Immunology

Based on material from 400-600 level Immunology courses, this concise and thorough review of modern concepts in molecular, cellular, and systemic immunology contains over two hundred detailed problems with step-by-step solutions. Taking a problem-solving approach, Schaum's Outline of Immunology is an excellent supplement to any systematic textbook of modern immunology, focusing on the basic tenets of immunology as applied to the dynamics of immune responses and their outcomes, and is perfect for pre-med students who need help in their required immunology courses, as well as for medical and veterinary students who want to update their knowledge.

Guide to Biotechnology

The biotechnology industry originated in the 1970s, based largely on a new recombinant DNA technique whose details were published in 1973 by Stanley Cohen of Stanford University and Herbert Boyer of the University of California, San Francisco. Recombinant DNA is a method of making proteins—such as human insulin and other therapies—in cultured cells under controlled manufacturing conditions. Boyer went on to co-found Genentech, which today is biotechnology’s largest company by market capitalization.

Microbiology in Action

microbes play an important role in our everyday lives. As agents of infectious disease, they cause untold human misery, yet their beneficial activities are manifold, ranging from the natural cycling of chemical elements to the production of food. In this introductory text, the authors provide a clear and accessible account of the interactions among microbes, their environments, and other organisms, citing examples of both beneficial and detrimental activities. The book begins by considering positive activities, focusing on environmental microbiology and manufacturing, and then moves on to consider some of the more adverse aspects of microbes, particularly the myriad diseases to which we are susceptible and the treatments currently in use. Microbiology in Action will prove to be a valuable text for those studying microbiology.

Basic Concepts in Biochemistry: A Student's Survival Guide

Do you find biochemistry daunting? If so, this time-saving guide offers all the help you need. Compact, yet comprehensive, the second edition of BASIC CONCEPTS IN BIOCHEMISTRY breaks down the complexities of biochemistry into jargon-free, easy-to-remember steps that show you how biochemistry works.And unline reviews that emphasize memorization of facts, this book helps you master the topics that students find most difficult, building your understanding with explanations in everyday language. You'll comprehend the material and feel more comfortable applying it. Along with enhanced figures, the new edition contains two new chapters - one that outlines the concepts of membranes and membrane

The Unwritten Rules of PhD Research

This book looks at things the other books don’t tell you about doing a PhD - what it’s really like and how to come through it with a happy ending! It covers all the things you wish someone had told you before you started:

•What a PhD is really about, and how to do one well
•The "unwritten rules" of research and of academic writing
•What your supervisor actually means by terms like "good referencing" and "clean research question"
•How to write like a skilled researcher
•How academic careers really work
An ideal resource if someone you care about (including yourself!) is undergoing or considering a PhD. This book turns lost, clueless students back into people who know what they are doing, and who can enjoy life again.

Principles of Cancer Genetics

Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparate pieces of highly specialized information is challenging for the professional scientist and student alike. Prinicples of Cancer Genetics consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. Focused on the most highly representative genes that underlie the most common cancers, Principles of Cancer Genetics is aimed at advanced undergraduates who have completed introductory courses in genetics, biology and biochemistry, medical students, and house medical house staff preparing for board examinations. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand. The many points of controversy in cancer research are avoided, in favor of firmly established concepts. This book does not delve into tumor pathobiology beyond what is required to understand the role of genetic alterations in neoplastic growth. For students with a general interest in cancer, this book will provide a highly accessible overview. For students contemplating future study in the fields of oncology or cancer research, this book will be useful as a primer

Genes 8

Genes 8 changed the approach to begin with the sequence of the human and other genomes and starts with complete coverage of recent advances in genomics. The coverage of genomics is then integrated throughout the text.Two decades ago Benjamin Lewin’s Genes revolutionized the way we think about and teach molecular biology and molecular genetics. His approach unified the discipline by providing an integrated account of the structure and function of genes in both prokaryotes and eukaryotes.
Setting a standard for currency, Genes continually embraces emerging trends in this field, such as introducing the molecular aspect of the gene before the traditional analysis of formal genetics. Genes VIII continues to innovate; expanding the early discussion of the genome and integrating new information on gene sequencing throughout the text.

The art of genes

I always had the feeling that evolution was the inventor of new things and development was a secondary problem of how to build an organism from information already present in the fertilised egg. Now I know what problems need to be solved in building a multicellular organism from a single cell in the first place. Enrico Coen magnificently explains how the head-tail, ventral-dorsal, left-right and inside-outside axis is build out of nearly nothing. The subtitle of the book is a perfect illustration of the task: How organisms make themselves (without help from outside). The problem looked only harder since the discovery of DNA : the information in DNA is one-dimensional, so how to build a 3-dimensional organism on the basis of that? No wonder that people in previous centuries saw miniature humans in egg or sperm. But since that 'solution' was refuted, the problem confronted us again: how do organisms make themselves? Enrico Coen gives deep insights with the help of metaphors derived from art and with the necessary scientific details and without confusing us with too many complexities. Coen explains the crucial role of genes without being a genetic reductionist. His examples are both from animals and plants, wich I find an advantage. This book is an achievement. The only criticism I have is that the main metaphor Coen uses is about colors and all the illustrations are in black-and-white! At least the hardback edition should have color illustrations