Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Safety aspects have become an outstanding issue in the process of drug discovery and development. Until 15 years ago, drug discovery and evaluation was a sequential process starting with the selection of the most active compound from a series of newly synthesized compounds by means of special pharmacological assays. Safety aspects were addressed by pharmacological testing of the selected compound in high doses in tests directed at indications other than the intended indication of the new compound. These tests were followed by pharmacokinetic studies, which were mainly aimed at confirming of a suitable half-life time and at oral activity. Safety aspects relied mostly on toxicity studies, which however gave information on changes of organ structure rather than on organ function.

Thinking about Biology

Intended for biology students, this philosophical commentary on biology makes science students' studies
more interesting by offering an easy way of studying the philosophy of science, as well as engaging in debates about the social and political implications of biology. It is a unique biology textbook because it adopts an explicitly philosophical approach.

Microbiological Applications:

The classic resource for undergraduate microbiologz laboratory courses just keeps getting better. The self-contained, clearly illustrated exercises and four-color format make Benson's Microbiological Applications: A Laboratory Manual in General Microbiology the ideal lab manual. Appropriate for either a majors or non-majors lab course, Benson assumes no prior organic chemistry
course has been taken.

Schaum's Outline of Immunology

Based on material from 400-600 level Immunology courses, this concise and thorough review of modern concepts in molecular, cellular, and systemic immunology contains over two hundred detailed problems with step-by-step solutions. Taking a problem-solving approach, Schaum's Outline of Immunology is an excellent supplement to any systematic textbook of modern immunology, focusing on the basic tenets of immunology as applied to the dynamics of immune responses and their outcomes, and is perfect for pre-med students who need help in their required immunology courses, as well as for medical and veterinary students who want to update their knowledge.

Guide to Biotechnology

The biotechnology industry originated in the 1970s, based largely on a new recombinant DNA technique whose details were published in 1973 by Stanley Cohen of Stanford University and Herbert Boyer of the University of California, San Francisco. Recombinant DNA is a method of making proteins—such as human insulin and other therapies—in cultured cells under controlled manufacturing conditions. Boyer went on to co-found Genentech, which today is biotechnology’s largest company by market capitalization.

Microbiology in Action

microbes play an important role in our everyday lives. As agents of infectious disease, they cause untold human misery, yet their beneficial activities are manifold, ranging from the natural cycling of chemical elements to the production of food. In this introductory text, the authors provide a clear and accessible account of the interactions among microbes, their environments, and other organisms, citing examples of both beneficial and detrimental activities. The book begins by considering positive activities, focusing on environmental microbiology and manufacturing, and then moves on to consider some of the more adverse aspects of microbes, particularly the myriad diseases to which we are susceptible and the treatments currently in use. Microbiology in Action will prove to be a valuable text for those studying microbiology.

Basic Concepts in Biochemistry: A Student's Survival Guide

Do you find biochemistry daunting? If so, this time-saving guide offers all the help you need. Compact, yet comprehensive, the second edition of BASIC CONCEPTS IN BIOCHEMISTRY breaks down the complexities of biochemistry into jargon-free, easy-to-remember steps that show you how biochemistry works.And unline reviews that emphasize memorization of facts, this book helps you master the topics that students find most difficult, building your understanding with explanations in everyday language. You'll comprehend the material and feel more comfortable applying it. Along with enhanced figures, the new edition contains two new chapters - one that outlines the concepts of membranes and membrane